Parallel-Stranded DNA Formed by New Base Pairs Related to the Isoguanine-Cytosine or Isocytosine-Guanine Motifs |
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| Authors: | Frank Seela Changfu Wei Alexander Melenewski Yang He Rita Kröschel Elisabeth Feiling |
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| Institution: | Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie , Universit?t Osnabrück, Barbarastr. 7, D-49069, Osnabrück, Germany |
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| Abstract: | Abstract Parallel-stranded (ps) oligonucleotide duplexes containing several new base pairs formed between 7-deazaisoguanine and cytosine, 8-aza-7-deaza-isoguanine and cytosine, and 5-aza-7-deaza guanine and guanine are described. The stability of the pshybrids increased if the duplex contains 8-aza-7-deazaisoguanine instead of isoguanine and is decreased by 7-deazaisoguanine incorporation. The purine-purine base pair between 5-aza-7-deazaguanine and guanine was found to be more stable than that of 5-methylisocytosine with guanine. |
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