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Efficient Chemical Synthesis of Oligonucleotides Containing the 2-Deoxyribonolactone Site |
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| Authors: | Mitsuharu Kotera Anne-Gaëlle Bourdat Eric Defrancq Muriel Jourdan Julian Garcia Christian Coulombeau |
| Institution: | Chimie Bioorganique, L.E.D.S.S., Associé au CNRS, Université , Joseph Fourier, BP 53, 38041, Grenoble Cedex, 9, France E-mail: mitsu.kotera@ujf-grenoble.fr |
| Abstract: | Abstract A highly efficient synthetic method for incorporation of the deoxyribonolactone lesion into oligonucleotides was developed using the photochemical properties of 7-nitroindole. |
| Keywords: | |