Crystal Structure of a Left-Handed Z-DNA Hexamer,d(CG)3, Duplex Complexed with Synthetic Polyamine Reveals Binding of a Polyamine in the Minor Groove |
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| Authors: | Ken-Ichi Tomita Hirofumi Ohishi Isao Nakanishi Toshio Hakoshima Alexander Rich |
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| Affiliation: | 1. Faculty of Pharmaceutical Sciences, Osaka University , Yamadaoka, Suita, 565-0871, Japan;2. Osaka University of Pharmaceutical Sciences , Nasahara, Takatsuki, Osaka, 569-1094, Japan;3. Fujisawa Pharmaceutical Co. , Kashima, Yodogawa-ku, Osaka, 532-0032, Japan;4. Department of Molecular Biology , Nara Institute of Sciences and Technology , Takayama, Ikoma, Nara, 630-0101, Japan;5. Department of Biology , Massachusetts of Technology , Cambridge, MA, 02139, U.S.A. |
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| Abstract: | Abstract As a series of X-ray structural studies of Z-DNA Polyamine complex, the crystal structure of Z-DNA hexamer, d(CG)3, duplex complexed with a synthetic polyamine, N,N′-bis(2-aminoethyl)-1,2-ethanediamine, NH2-(CH2)2-NH-(CH2)2-NH-(CH2)2-NH2 [PA(222)], has been determined. |
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