Pharmacologic Disposition of a Phosphorothioate Oligodeoxynucleotide in Mice |
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| Authors: | Rosanne M. Orr Florence I. Raynaud Phyllis M. Goddard Ian R. Judson Terry Beck Bob Bryant |
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| Affiliation: | 1. CRC Centre for Cancer Therapeutics , The Institute of Cancer Research , Sutton, Surrey, UK;2. Genta Inc. , San Diego, CA, USA |
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| Abstract: | Abstract G3139, an 18mer phosphorothioate (S-labeled), was administered to mice by single i.v. bolus or continuous S.C. infusion. The latter schedule resulted in reduced liver metabolism and urinary excretion together with greater tissue accumulation, in particular to the liver, kidney and bone marrow, probably reflecting the dose received. |
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