Synthesis of a 2-Hydroxy-oxolane Derivative as a New Potential Crosslinking Agent of DNA |
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| Authors: | L Nzita S Ladame L Gomez S Moreau |
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| Institution: | INSERM U-386, IFR Pathologies Infectieuses Université Victor Segalen Bordeaux II , 146 rue Léo Saignat, F-33076, Bordeaux Cedex, France |
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| Abstract: | Abstract The design and the synthesis of a new potential crosslinking agent of DNA is reported. It is based on the alkylating properties of a natural toxin (botryodiplodin) and will be further linked to antisense oligonucleotides. |
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