A New H-Phosphonate Approach Using N-Unprotected Monomers and Phosphonium Condensing Reagents |
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| Authors: | Takeshi Wada Yuichi Sato Fumio Honda Shun-Ichi Kawahara Akira Mochizuki Mitsuo Sekine |
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| Affiliation: | Department of Life Science , Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology , Nagatsuta, Midoriku, Yokohama, 226-8501, Japan |
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| Abstract: | Abstract Oligodexyribonucleotides were synthesized by using N-unprotected H-phosphonate monomers and a phosphonium-type of new condensing reagent. In the present H-phosphonate approach, N-sulfonyloxaziridine derivatives were successfully employed as new reagents for oxidation of the H-phosphonate linkages in the presence of silylating reagents. |
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