Oligonucleotide Conjugates Derived from an Electrophilic Site: Conjugation to Baseless Carbohydrate Residue. Synthesis,Hybridization and Modeling Studies |
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Authors: | Muthiah Manoharan Laura K. Andrade Venkatraman Mohan Susan M. Freier P. Dan Cook |
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Affiliation: | Isis Pharmaceuticals , 2292 Faraday Ave., Carlsbad, CA, 92008, USA |
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Abstract: | Abstract Conjugation of electrophiles to oligonucleotides via tethers camying nucleophilic sites well-known. However, for the rever.se reaction, the availahlc methods to generate electrophilic sites in oligonucleotides are not many: (e.g., periodate oxidation of terminal rihose sugar followed by reductive amination). |
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