5-Deazaflavins: New Very Efficient DNA Photosensitisers,Synthesis of Oligonucleotide Conjugates |
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| Authors: | I Girault J L Ravanat C Frier M Fontecave J Cadet J L Décout |
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| Institution: | 1. Laboratoire de Chimie et Biochimie des Centres Rédox Biologiques , DBMS-CEA/EP CNRS 1087/Université J. Fourier, avenue des Martyrs 38054, Grenoble Cedex, 9, France;2. Laboratoire des Lésions des Acides Nucléiques , SCIB-CEA Grenoble, 17 avenue des Martyrs, 38054, Grenoble Cedex, 9, France;3. Groupe de Pharmacochimie Moléculaire , EP CNRS 811, Domaine de la Merci, 38000, La Tronche, France |
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| Abstract: | Abstract In order to study electron transfer processes through the DNA double helix, we have synthesised a series of 5-deazaflavin derivatives 1–4 and demonstrated their ability to induce very efficiently 2′-deoxyguanosine and DNA oxidations by electron transfer from guanine. 5-Deazaflavin-oligonucleotide adducts were also synthesised for the study of electron transfers through double or triple helix formed with their complementary sequence. |
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