A Versatile Polymer Support Useful for Large-Scale Synthesis of DNA for Biomedical Applications |
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| Authors: | P. Jaisankar # M. Hinz E. Happ H. Seliger |
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| Affiliation: | 1. Division of Medicinal Chemistry, Indian Institute of Chemical Biology , (C.S.I.R) 4. Raja S.C. Mullick Road, Calcutta , 700 032 , India;2. University of Ulm, Section of Polymers , Albert-Einstein-Allee, 11 D-89069 , Ulm , Germany |
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| Abstract: | Abstract A suitably derivatized MercKogelR 1 as an efficient solid support for the large-scale synthesis of DNA for biomedical applications, is described. Partial hydrolysis of these polyvinylacetate resins with 0.5 M NaOH solution1 at room temperature for 30–80 min. yielded carriers 1 that could be loaded with 120, 150, 258, and 368 μmoles of nucleosides g?1. |
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