New Phosphitylating Reagents Containing P-F Bond and Their Application in the Synthesis of P-Fluoro Nucleosidyl Phosphates,Thiophosphates and Selenophosphates |
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Authors: | W Dąbkowski I Tworowska E Poniatowska J Michalski F Cramer |
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Institution: | 1. Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences , 90-363 ?ód?, Sienkiewicza, 112, Poland;2. Max-Planck-Institut für experimentelle Medizin , 3400 G?ttingen, Hermann-Rein Strasse, 3, Germany |
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Abstract: | Abstract An efficient and general synthesis of phosphorofluoridates RO-P(X)(OH)F (X=O) and their analogues (X=S, Se) based on two new phosphitylating reagents: 2-cyanoethyl-N,N-diisopropylfluorophosphoroamidite F-P(NPri 2)OCH2CH2CN and tertbutyl-N,N-diisopropylfluorophosphoroamidite F-P(NPri 2)OBut is described. |
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