Synthesis of Oligonucleotide-Intercalator Conjugates Capable to Inhibit HIV-1 DNA Integration |
| |
| Authors: | M. B. Gottikh E. M. Volkov E. A. Romanova T. S. Oretskaya Z. A. Shabarova |
| |
| Affiliation: | A. N. Belozersky Institute of Physical Chemical Biology, Lomonosov Moscow State University , Moscow, 119899, Russia |
| |
| Abstract: | Abstract This investigation is devoted to design of short “switch” oligonucleotides mono- or bi-functionnalized with intercalating agents capable to form a stable triplex with HIV integrase-cognate sequences and inhibit selectively HIV integration. Methods of intercalator incorporation at 5′- and/or 3′-terminal positions or one of the pyrimidine heterocyclic bases are developed. |
| |
| Keywords: | |
|
|
