Special Properties of Modification of SsDNA Target by Alkylating Derivatives of Oligonucleotides in Tandem Complexes |
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| Authors: | D V Pyshnyi S G Lokhov E M Ivanova V F Zarytova |
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| Institution: | Novosibirsk Institute of Bioorganic Chemistry , Novosibirsk , Russia |
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| Abstract: | Abstract The influence of an effector (di-N-(2-hydroxyethyl)-phenazinium derivative of oligonucleotide) on modification of the DNA target by alkylating derivatives of oligonucleotides having various hybridization properties was studied. Being adjacent to the alkylating group of the reagent, the effector enhances the target modification if the oligonucleotide reagent has low hybridization properties and suppresses the modification if the reagent can form the stable complex with the DNA target at the used conditions. |
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