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Cleavage of Leishmania Mini-exon Sequence by Oligonucleotides Conjugated to a Dimidazole Construction |
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| Authors: | Ludmila Yurchenko Vladimir Silnikov Tatyana Godovikova Gennady Shishlan Jean-Jacques Toulme Valentin Vlassov |
| Institution: | 1. Institute of Bioorganic Chemistry, Siberian Division of the Russian Academy of Sciences , 8 Lavrentiev Avenue, Novosibirsk, 630090, Russia;2. Universite de Bordeaux II , 146, rue Leo Saignat, 33076, Bordeaux Cedex, France |
| Abstract: | Abstract RNA sequences derived from the Leishmania amazonensis mini-exon and pre-mini-exon sequences have been targeted with complementary oligonucleotides bearing a diimidazole construction mimicking active center of ribonuclease A. The conjugates were shown to cleave the target RNAs at specific positions. |
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