| 不同年龄大鼠尿液代谢组学研究 |
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| 引用本文： | 杨玉萍,张霞,王翀翀,王晓艳. 不同年龄大鼠尿液代谢组学研究[J]. 生物技术通报, 2022, 0(2): 166-172 |
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| 作者姓名： | 杨玉萍 张霞 王翀翀 王晓艳 |
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| 作者单位： | 上海交通大学系统生物医学研究院系统生物医学教育部重点实验室 |
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| 基金项目： | 国家自然科学基金项目(30901997,31972935);国家重点基础研究发展计划(973)项目(2012CB910102);上海交通大学生物医学工程交叉研究基金项目(17X190020020,18X190020070)。 |
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| 摘 要： | 旨在探究健康大鼠的尿液代谢物在生长、发育和衰老过程中的年龄相关性变化.采集大鼠出生后3周、5周、7周、9周、12周、56周和111周共7个年龄点的尿液样本,利用GC/TOF-MS平台进行代谢组学检测.结果显示,所有尿液样本在主成分分析与偏最小二乘法判别分析中出现组内聚类和组间分离.氨基酸类、有机酸类和碳水化合物类代谢物...
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| 关 键 词： | 生长 发育 衰老 代谢组学 尿液代谢物 |
Study on Urine Metabolomics in Rats of Different Ages |
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| YANG Yu-ping,ZHANG Xia,WANG Chong-chong,WANG Xiao-yan. Study on Urine Metabolomics in Rats of Different Ages[J]. Biotechnology Bulletin, 2022, 0(2): 166-172 |
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| Authors: | YANG Yu-ping ZHANG Xia WANG Chong-chong WANG Xiao-yan |
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| Affiliation: | (Ministry of Education Key Laboratory of Systems Biomedicine,Shanghai Center for Systems Biomedicine,Shanghai Jiao Tong University,Shanghai 200240) |
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| Abstract: | This work aims to explore the age-related changes of urine metabolites in healthy rats during growth,development and aging.Urine samples were collected at 3,5,7,9,12,56,and 111 weeks after birth,and the GC/TOF-MS platform was employed for metabolomics detection.The results showed that all urine samples appeared in-group clustering and between-group separation in principal component analysis and partial least square discriminant analysis.Amino acids,organic acids,and carbohydrates were the dominant metabolite types in the rat urine samples.The levels of urine metabolites such as 4-hydroxyproline,L-lysine,and uric acid gradually decreased with age.D-ribose,aconitic acid,and fumaric acid increased in old age,while nicotinic acid and 5-hydroxyindole decreased in old age.The above results revealed that age affected urine metabolism in rats,and a variety of urine metabolites appeared age-related changes during growth,development and aging. |
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| Keywords: | growth development aging metabolomics urine metabolites |
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