Vasopressin increases 45Ca2+ influx in rat aortic smooth muscle cells |
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| Authors: | A Walln?fer C Cauvin U T Rüegg |
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| Affiliation: | Preclinical Research, Sandoz Ltd., Basel, Switzerland. |
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| Abstract: | [Arg8]Vasopressin (AVP)-induced 45Ca2+ influx was examined in vascular smooth muscle cells derived from rat aorta. AVP stimulated the 45Ca2+ influx in a concentration-dependent manner. The effect was abolished in the presence of La3+. The dihydropyridine calcium channel antagonist darodipine did not affect the AVP-induced influx of 45Ca2+. These data suggest that AVP stimulates in these cultured aortic smooth muscle cells a receptor-operated channel (ROC) that is permeable to Ca2+. |
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