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Classification of Myoviridae bacteriophages using protein sequence similarity
Authors:Rob Lavigne  Paul Darius  Elizabeth J Summer  Donald Seto  Padmanabhan Mahadevan  Anders S Nilsson  Hans W Ackermann  Andrew M Kropinski
Affiliation:(1) Biosystems Department, Katholieke Universiteit Leuven, Kasteelpark Arenberg 21, Leuven, B-3001, Belgium;(2) Center for Phage Therapeutics, Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA;(3) Department of Bioinformatics and Computational Biology, George Mason University, Manassas, VA20110, USA;(4) Department of Genetics, Microbiology and Toxicology, Stockholm University, 91 Stockholm, S-106, Sweden;(5) Felix d'Herelle Reference Center for Bacterial Viruses, Department of Medical Biology, Faculty of Medicine, Laval University, Quebec, QC, G1K 4C6, Canada;(6) Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, 110 Stone Road West, Guelph, ON, N1G 3W4, Canada;(7) Department of Molecular & Cellular Biology, University of Guelph, Guelph, ON, N1G 2W1, Canada
Abstract:

Background  

We advocate unifying classical and genomic classification of bacteriophages by integration of proteomic data and physicochemical parameters. Our previous application of this approach to the entirely sequenced members of the Podoviridae fully supported the current phage classification of the International Committee on Taxonomy of Viruses (ICTV). It appears that horizontal gene transfer generally does not totally obliterate evolutionary relationships between phages.
Keywords:
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