Hepatitis a virus infection of HBsAg-producing hepatocellular carcinomas in athymic mice |
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| Authors: | Verena Gauss-Müller Friedrich Deinhardt Eckhart Hahn Rolf Lamerz |
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| Institution: | (1) Max von Pettenkofer Institute, University of Munich, Pettenkoferstrasse 9a, D-8000 München 2;(2) Universitätsklinikum Steglitz, Hindenburgdamm 30, D-1000 Berlin 45;(3) Medizinische Klinik II, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, D-8000 Munich 70, Federal Republic of Germany |
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| Abstract: | Summary Two human hepatocellular carcinoma cell lines were grown in athymic mice. Morphologically, the tumors resembled hepatocellular carcinomas. HBsAg, anti-HBs, and  -fetoprotein were detected in sera of mice bearing tumors of PLC/PRF/5 or Hep 3B cells; their amounts correlated with tumor weight. Tumors of both cell lines were infected with cell culture-adapted hepatitis A virus (HAV); HAV antigen and infectious virus were recovered from infected tumors of PLC/PRF/5 and Hep 3B cells. Our results indicate that HAV-infected tumors may be useful in studying the production in vivo of hepatitis A virus antigen. |
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