Transforming growth factor beta family expression at the bovine feto-maternal interface |
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| Authors: | Kumiko Sugawara Keiichiro Kizaki Chandana B Herath Yoshihisa Hasegawa Kazuyoshi Hashizume |
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| Institution: | 1.Laboratory of Veterinary Physiology,Department of Veterinary Medicine, Iwate University,Morioka,Japan;2.Current address:Agricultural Mutual Relief Association Joint Association in Miyagi Prefecture,Osaki-shi,Japan;3.Laboratory of Reproductive Endocrinology, Department of Developmental Biology,National Institute of Agrobiological Sciences,Tsukuba,Japan;4.Current address: Department of Medicine,The University of Melbourne, Austin Repatriation Hospital, Heidelberg Heights,Australia;5.Kitasato University School of Veterinary Medicine,Towada,Japan |
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| Abstract: | Background Endometrial remodelling is necessary for implantation in all mammalian species. The TGF beta super-family plays a crucial
role in this event in humans and mice. However, the role of TGF beta super-family members during implantation is still unclear
in ruminants. In the present study, the spacio-temporal expression of TGF beta super-family members including activin was
explored in bovine trophoblasts and endometrial tissue during the peri-implantation period in order to elucidate whether it
is essential for promoting cell proliferation at the implantation site. |
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