Synthesis and antibacterial activity of 1-[1,2,4-triazol-3-yl] and 1-[1,3,4-thiadiazol-2-yl]-3-methylthio-6,7-dihydrobenzo[c]thiophen-4(5H)ones |
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| Authors: | Tehranchian Sara Akbarzadeh Tahmineh Fazeli Mohammad Reza Jamalifar Hossein Shafiee Abbas |
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| Institution: | Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran. |
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| Abstract: | A series of 1-1,2,4-triazol-3-yl] and 1-1,3,4-thiadiazol-2-yl]-3-methylthio-6,7-dihydrobenzoc]thiophen-4(5H)ones were synthesized and tested to demonstrate in vitro antimicrobial activity. Some of these compounds exhibited a good activity against Staphylococcus aureus, S. epidermidis and Bacillus subtilis. |
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