Hepatitis B Virus Infection of a Mouse Hepatic Cell Line Reconstituted with Human Sodium Taurocholate Cotransporting Polypeptide |
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| Authors: | Florian A. Lempp Bingqian Qu Yong-Xiang Wang Stephan Urban |
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| Affiliation: | aDepartment of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany;bKey Laboratory of Medical Molecular Virology, Institute of Medical Microbiology, Shanghai Medical College, Fudan University, Shanghai, China;cGerman Center for Infection Research (DZIF), Heidelberg, Germany |
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| Abstract: | Hepatitis B virus (HBV) enters hepatocytes via its receptor, human sodium taurocholate cotransporting polypeptide (hNTCP). So far, HBV infection has been achieved only in human hepatic cells reconstituted with hNTCP and not in cells of mouse origin. Here, the first mouse liver cell line (AML12) which gains susceptibility to HBV upon hNTCP expression is described. Thus, HBV infection of receptor-expressing mouse hepatocytes does not principally require a human cofactor but can be triggered by endogenous murine determinants. |
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