Novel Feline Leukemia Virus Interference Group Based on the env Gene |
| |
| Authors: | Ariko Miyake Shinya Watanabe Takahiro Hiratsuka Jumpei Ito Minh Ha Ngo Isaac Makundi Junna Kawasaki Yasuyuki Endo Hajime Tsujimoto Kazuo Nishigaki |
| |
| Institution: | aLaboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan;bLaboratory of Small Animal Internal Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan;cDepartment of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan |
| |
| Abstract: | Feline leukemia virus (FeLV) subgroups have emerged in infected cats via the mutation or recombination of the env gene of subgroup A FeLV (FeLV-A), the primary virus. We report the isolation and characterization of a novel env gene, TG35-2, and report that the TG35-2 pseudotype can be categorized as a novel FeLV subgroup. The TG35-2 envelope protein displays strong sequence identity to FeLV-A Env, suggesting that selection pressure in cats causes novel FeLV subgroups to emerge. |
| |
| Keywords: | |
|
|
