Immune Profiles to Predict Response to Desensitization Therapy in Highly HLA-Sensitized Kidney Transplant Candidates |
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| Authors: | Julie M Yabu Janet C Siebert Holden T Maecker |
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| Institution: | 1Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, United States of America;2CytoAnalytics, Denver, CO, United States of America;3Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Palo Alto, CA, United States of America;University of Toledo, UNITED STATES |
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| Abstract: | BackgroundKidney transplantation is the most effective treatment for end-stage kidney disease. Sensitization, the formation of human leukocyte antigen (HLA) antibodies, remains a major barrier to successful kidney transplantation. Despite the implementation of desensitization strategies, many candidates fail to respond. Current progress is hindered by the lack of biomarkers to predict response and to guide therapy. Our objective was to determine whether differences in immune and gene profiles may help identify which candidates will respond to desensitization therapy.ConclusionsMeasuring baseline and longitudinal immune and gene profiles could provide a useful strategy to distinguish responders from non-responders to desensitization therapy. This study presents the integration of novel translational studies including CyTOF immunophenotyping in a multivariate analysis model that has potential applications to predict response to desensitization, select candidates, and personalize medicine to ultimately improve overall outcomes in highly sensitized kidney transplant candidates. |
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