Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives |
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| Authors: | Shinozaki K Sato H Iwakuma T Sato R Kurimoto T Yoshida K |
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| Institution: | Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Ohsatogun, Saitama, Japan. |
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| Abstract: | A new series of indane derivatives were prepared and evaluated for their thromboxane A2 (TXA2, 1) antagonistic activity. Among these compounds, 24a (Z-335) was found to be a potent TXA2 antagonist in oral administration. |
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