Expression of CXCR4 on feline peripheral blood mononuclear cells: effect of feline immunodeficiency virus infection |
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| Authors: | Willett Brian J Cannon Celia A Hosie Margaret J |
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| Institution: | Retrovirus Research Laboratory, Institute of Comparative Medicine, Department of Veterinary Pathology, University of Glasgow, United Kingdom. b.willett@vet.gla.ac.uk |
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| Abstract: | CXCR4 expression on feline peripheral blood mononuclear cells (PBMC) was analyzed. While monocytes and B lymphocytes expressed CXCR4, no CXCR4 was detected on T lymphocytes, in stark contrast to the expression pattern on T lymphocytes from humans. In spite of the important role that CXCR4 plays in infection with feline immunodeficiency virus, expression on PBMC in vivo was unaffected by infection with either a primary or a cell culture-adapted virus strain. |
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