Nucleoprotein methylation in salivary gland chromosomes of Sciara coprophila: Correlation with DNA synthesis |
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Authors: | Reba M. Goodman Wm B. Benjamin |
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Abstract: | Methylation and ethylation of chromosomal nucleoproteins have been demonstrated in the salivary glands of Sciara coprophila larvae. A difference in grain distribution pattern was observed between chromosomes incubated in 3H-methyl-methionine and 3H-ethyl-ethionine. Like DNA synthesis, methylation could only be demonstrated at certain developmental stages, and during some of these a close correlation was observed between labelling patterns following 3H-methyl-methionine and 3H-thymidine in separated gland pairs. No such correlation was observed with RNA synthesis. Ethylation of chromosomal non-histone protein could not be correlated with nucleic acid biosynthesis. Feeding ethionine during larval development produced similar nucleolar abnormalities to those previously described in rat liver nucleoli. |
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