Comparative effects of tretamine,tepa, apholate and their structural analogs on human chromosomes in vitro |
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| Authors: | Tsueng-Hsing Chang Waldemar Klassen |
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| Affiliation: | (1) The Lancaster Cleft Palate Clinic, H. K. Cooper Institute for Research, Education and Rehabilitation, Lancaster, Pa.;(2) Entomology Research Division, Agriculture Research Service, United States Department of Agriculture, Metabolism and Radiation Research Laboratory, Fargo, North Dakota |
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| Abstract: | Breakage of human chromosomes was studied in vitro by treating leukocyte cultures for 8 hours with tretamine, tepa, hempa, hemel, and apholate. The aziridines tretamine, tepa, and apholate effectively induced aberrations; the dimethylamino compounds, hemel and hempa, induced few. Tretamine, the most effective compound, induced aberrations in 78% of the cells; hempa, the least effective, induced aberrations in 14%, even at a 1000-fold greater molar concentration. Abberations occurred in 6% of control cells. The gaps and breaks were induced randomly among cells. |
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