Effect of sigmaS on sigmaE-directed cell lysis in Escherichia coli early stationary phase |
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Authors: | Kabir Md Shahinur Yamashita Daisuke Noor Rashed Yamada Mamoru |
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Institution: | Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan. |
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Abstract: | The sigmaE regulon has been shown to perform a novel function that causes dead-cell lysis specific to the early stationary phase in addition to its well-known role in the extracytoplasmic stress response in Escherichia coli. Here, the effect of sigmaS as a general stress-responsive sigma factor on sigmaE-directed cell lysis was investigated. The lysis phenomena were observed in both rpoS mutant and parental strains constitutively expressing active sigmaE, but the former lysis occurred at a relatively early stage compared to the latter. Based on these results and experiments with hydrogen peroxide, we propose that some stresses generate living but non-culturable cells, which are subject to sigmaE-directed cell lysis. |
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