Studies on the interaction between mitochondria and the cytoskeleton |
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Authors: | Monica Lindén B. Dean Nelson Dragutin Loncar Jean Francois Leterrier |
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Affiliation: | (1) Department of Biochemistry, University of Stockholm, S106 91 Stockholm, Sweden;(2) The Wenner Gren Institute, University of Stockholm, S106 91 Stockholm, Sweden;(3) NSERM U 298, Centre Hospitalier Régional Universitaire, 49033 Angers Cedex, France |
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Abstract: | Mitochondrial movements and morphology are regulated through interactions with the cytoskeletal system, in particular the microtubules. An interaction between the microtubule-associated proteins (MAPs) and the outer surface of rat brain mitochondria has been demonstratedin vitro andin situ. One of the MAPs, MAP2, binds to specific high-affinity sites on the outer membrane. Upon binding, MAP2 is released from microtubules, and it induces a physical alteration in the outer membrane which is characterized by a tighter association of porin with the membrane. It is concluded that MAP2 either binds to porin or to a domain of the outer membrane which alters the membrane environment of porin. The possibility is raised that this domain participates in mitochondrial mobilityin situ. |
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Keywords: | Mitochondria microtubules microtubule-associated proteins (MAPs) cytoskeleton porin Voltage-dependent anion-selective channels |
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