促细胞凋亡因子Bid蛋白的研究进展

Bid蛋白是Bcl-家族中促凋亡类的蛋白。它具有可被caspase8酶切高控、高效地诱民细胞色素c从线粒体泄漏到胞浆中的功能，从而在细胞凋亡中起着重要的作用，因而倍受人们的重视。Bid蛋白的功能被发现以来，短短几年间，人们从分子生物学、细胞学、结构分析以及利用脂质体模型膜体系等各方面对Bid蛋白进行研究，取得了很大的进展。

ADVANCE ON THE STUDIES OF PROAPOPTOTIC BID PROTEIN

Bid is a proapoptotic member of the Bcl-2 family that shares only the BH3 domain. The full-length Bid is inactive. Cleaved by caspase 8, the carboxy-terminal portion of Bid then translocates to mitochondria and is sufficient to trigger cytochrome c release. This is the key regulatory step in apoptosis. Within only few years after the function of Bid was found, the studies of different approaches of molecular biology, cell biology, structural analysis and the use of model membrane system had led to a rapid progress in the study of Bid protein. This minireview focuses on the brief story of Bid protein.