Salicylates inhibit paf-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective |
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| Institution: | 1. Instituto Oswaldo Cruz - Departamento de Fisiologia e Farmacodinâmica - Av. Brasil, 4365, CEP: 20010 Rio de Janeiro, Brasil;2. Unité Associée - Institut Pasteur / INSERM n: 285 25 Rue du Roux 75015 - Paris - France;1. Institute of Transfusion Medicine, Hannover Medical School, Hannover, 30625, Germany;2. INSERM Unit 955, Equipe 12, Faculty of Medicine, University Paris-Est, Créteil, France;3. Institute of Experimental Ophthalmology, Hannover Medical School, Hannover, 30625, Germany;4. Department of Nephrology, Hannover Medical School, Hannover, 30625, Germany;1. School of Pharmacy and Medical Sciences, Division of Health Sciences, Health and Biomedical Innovation Research Concentration, University of South Australia, Adelaide, South Australia, Australia;2. School of Health Sciences, Division of Health Sciences, Health and Biomedical Innovation Research Concentration, University of South Australia, Adelaide, South Australia, Australia;3. School of Pharmaceutical Sciences, Key Laboratory of Chemical Biology, Ministry of Education, Shandong University, Jinan, 250012, China |
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| Abstract: | The cyclooxygenase inhibitors indomethacin, piroxicam, ibuprofen, naproxen and flurbiprofen failed to block rat paw oedema induced by PAF-acether, whereas aspirin and sodium salicylate were effective. Two mixed cyclooxygenase and lipoxygenase inhibitors NDGA, BW 755C and dexamethasone reduced oedema in a dose — dependently. The selective PAF-acether antagonist, BN 52021, was effective against PAF-acether at 5 – 20 mg/kg. The lipoxygenase derivates may be involved in paw oedema induced by PAF-acether in the rat and the inhibition produced by aspirin and by sodium salicylate should involve mechanisms other than the cyclooxygenase pathway. |
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