Continuous subcutaneous infusion of follicle stimulating hormone as a method of superovulating dairy cows |
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| Affiliation: | 1. State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China;2. University of Chinese Academy of Sciences, Beijing 100190, People’s Republic of China;3. CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, People’s Republic of China;1. Sri Aurobindo Institute of Pharmacy, Indore, Madhya Pradesh, India;2. Faculty of Pharmacy, Philadelphia University, Amman, Jordan;3. National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Gandhinagar, Gujarat, India;4. Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia;2. Veterinary Medicine Teaching and Research Center, University of California–Davis, 18830 Road 112, Tulare 93274;1. Division of Life Science, Incheon National University, Incheon, 22012, South Korea;2. Bio-Resource and Environmental Center, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea |
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| Abstract: | Twenty-eight Holstein cows were randomly assigned to two treatments. Group I received 50 mg of follicle stimulating hormone-pituitary (FSH-P) intramuscularly (i.m.) in declining doses in 5 d. Group II received 49 mg of FSH-P in 7 d via constant-infusion, subcutaneously (s.c.) implanted osmotic pumps. Cows received 25 mg prostaglandin F2α 48 h after initiation of treatment and were inseminated at estrus. Intramuscular injections resulted in higher numbers of corpora lutea (CL) and embryos than the s.c. infusion. These differences were largely attributed to differences in the doses of FSH-P administered in the two groups. It was concluded that continuously infusing FSH-P s.c. via osmotic pumps can be used as a method of superovulating dairy cows. |
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