A complex solution to a sexual dilemma |
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| Authors: | Kuwabara Patricia E |
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| Institution: | Department of Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom. p.kuwabara@bristol.ac.uk |
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| Abstract: | The C. elegans male sex-determining protein, FEM-1, has been identified as a substrate recognition subunit of a Cullin-2 ubiquitin ligase complex. This complex controls the level of TRA-1A, a Ci/Gli homolog and master regulator of sex determination, by ubiquitin-mediated proteolysis. |
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