Aggregation,Phase Separation and Spatial Morphologies of the Assemblies of FG Nucleoporins |
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Authors: | Anton Zilman |
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Affiliation: | Department of Physics and Institute for Biomaterials and Biomedical Engineering, University of Toronto, 60 St George st, Toronto, ON, M5S1A7, Canada |
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Abstract: | Nuclear pore complex (NPC) is a biomolecular “nanomachine” that controls nucleocytoplasmic transport in eukaryotic cells. The key component of the functional architecture of the NPC is the assembly of intrinsically disordered proteins that line its passageway and play a central role in the NPC transport mechanism. Due to paucity of experimental methods capable to directly probe the morphology of this assembly in intact NPCs, much of our knowledge about its properties derives from in vitro experiments augmented by theoretical and computational modeling. I review the major insights into the biophysics of the assemblies of the intrinsically disordered proteins of the NPC arising from the theoretical analysis of the recent in vitro experimental results, with the emphasis on the phase separation and aggregation phenomena. |
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Keywords: | intrinsically disordered proteins nuclear pore complex phase separation NPCs nuclear pore complexes NTRs nuclear transport receptors |
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