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Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury |
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| Authors: | Hayashida Kentaro Sano Motoaki Ohsawa Ikuroh Shinmura Ken Tamaki Kayoko Kimura Kensuke Endo Jin Katayama Takaharu Kawamura Akio Kohsaka Shun Makino Shinji Ohta Shigeo Ogawa Satoshi Fukuda Keiichi |
| Affiliation: | a Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo 160-8582, Japan b Division of Cardiology, Keio University School of Medicine, Tokyo 160-8582, Japan c Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan d Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Saitama 332-0012, Japan e Department of Biochemistry and Cell Biology, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki city 211-8533, Japan f Department of Biochemistry and Cell Biology, The Center of Molecular Hydrogen Medicine, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki city 211-8533, Japan |
| Abstract: | Inhalation of hydrogen (H2) gas has been demonstrated to limit the infarct volume of brain and liver by reducing ischemia-reperfusion injury in rodents. When translated into clinical practice, this therapy must be most frequently applied in the treatment of patients with acute myocardial infarction, since angioplastic recanalization of infarct-related occluded coronary artery is routinely performed. Therefore, we investigate whether H2 gas confers cardioprotection against ischemia-reperfusion injury in rats. In isolated perfused hearts, H2 gas enhances the recovery of left ventricular function following anoxia-reoxygenation. Inhaled H2 gas is rapidly transported and can reach ‘at risk’ ischemic myocardium before coronary blood flow of the occluded infarct-related artery is reestablished. Inhalation of H2 gas at incombustible levels during ischemia and reperfusion reduces infarct size without altering hemodynamic parameters, thereby preventing deleterious left ventricular remodeling. Thus, inhalation of H2 gas is promising strategy to alleviate ischemia-reperfusion injury coincident with recanalization of coronary artery. |
| Keywords: | Ischemia-reperfusion injury Anti-oxidant Myocardial infarction H2 |
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