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The role of endogenous opioids in the protective effects of local sublethal hyperthermia against the progression of burn injury |
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| Authors: | Neda Karimi Zuhair Muhammad Hassan Morteza Behnam Rasuli Behrouz Ilkhanizadeh Shaker Salarilak Shahram Shahabi |
| Institution: | 1. Department of Biology, Faculty of Sciences, Ferdowsi University of Mashad, Mashad, Iran;2. Department of Immunology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran;3. Department of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;4. Department of Health and Community Medicine, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;5. Department of Microbiology, Immunology and Genetics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran |
| Abstract: | The aim of the present study was to evaluate the role of endogenous opioids in local sublethal hyperthermia-induced protection against burn injury.Second-degree burn wounds were induced on the back of Balb/c mice. Progression of burn injury and expression of heat shock protein (HSP)-70 were evaluated after 24 h.Both inhibition of HSP synthesis and blocking opioid receptors before applying local sublethal hyperthermia decreased the protective effects of sublethal hyperthermia against the progression of burn injury. Blocking opioid receptors attenuated induction of HSP-70 by sublethal hyperthermia. |
| Keywords: | Sublethal hyperthermia Thermotolerance Burn Endogenous opioids HSP-70 |
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