MicroRNA-23b downregulates peroxiredoxin III in human prostate cancer |
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Authors: | He Hui-chan Zhu Jian-guo Chen Xi-bin Chen Shan-ming Han Zhao-dong Dai Qi-shan Ling Xiao-hui Fu Xin Lin Zhuo-yuan Deng Ye-han Qin Guo-qiang Cai Chao Chen Jia-hong Zhong Wei-de |
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Institution: | Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First Municipal People's Hospital, Affiliated Guangzhou Medical College, Guangzhou 510180, China. |
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Abstract: | To investigate the mechanism by which peroxiredoxin III (PRDX3) is altered in human prostate cancer (PCa), we used microRNA (miRNA) target prediction program and miRNA microarray to predict and identify miR-23b as a candidate miRNA that targets PRDX3. We showed that miR-23b suppresses PRDX3 protein expression in human DU145 cells under normal and hypoxic conditions. Additionally, the clinical significance of miR-23b and PRDX3 expression in PCa patients was also confirmed. In conclusion, our data suggest that the effects of PRDX3 in PCa progression may be caused by the regulation function of miR-23b, and consequently, miR-23b may be involved in the response of PCa cells to hypoxia stress. |
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