The modeling and simulation of visuospatial working memory |
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Authors: | Lina Liang Rubin Wang Zhikang Zhang |
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Institution: | (1) Institute for Cognitive Neurodynamics, School of Information Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, People’s Republic of China; |
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Abstract: | Camperi and Wang (Comput Neurosci 5:383–405, 1998) presented a network model for working memory that combines intrinsic cellular bistability with the recurrent network architecture
of the neocortex. While Fall and Rinzel (Comput Neurosci 20:97–107, 2006) replaced this intrinsic bistability with a biological mechanism-Ca2+ release subsystem. In this study, we aim to further expand the above work. We integrate the traditional firing-rate network
with Ca2+ subsystem-induced bistability, amend the synaptic weights and suggest that Ca2+ concentration only increase the efficacy of synaptic input but has nothing to do with the external input for the transient
cue. We found that our network model maintained the persistent activity in response to a brief transient stimulus like that
of the previous two models and the working memory performance was resistant to noise and distraction stimulus if Ca2+ subsystem was tuned to be bistable. |
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Keywords: | Working memory Bistability Computational model Calcium signaling |
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