|
|||||
|
|
ANTINEOPLASTIC ACTIVITY OF CULTURED BLUE-GREEN ALGAE (CYANOPHYTA)1 |
|
| Authors: | Gregory M. L. Patterson Cynthia L. Baldwin Christine M. Bolis Faith R. Caplan Helen Karuso Linda K. Larsen Ira A. Levine Richard E. Moore Carrie S. Nelson Kathryn D. Tschappat Grace D. Tuang Eiichi Furusawa Shinobu Furusawa Ted R. Norton Richard B. Raybourne |
| Abstract: | A large-scale screening program was initiated to evaluate laboratory-cultured blue-green algae (cyanobacteria) as a source of novel antineoplastic agents. Approximately 1000 cyanophyte strains from diverse habitats were cultured to provide extracts for testing. The screening program identified the families Scytonemataceae and Stigonemataceae as prolific producers of novel cytotoxic compounds. Rates of rediscovery of known compounds were relatively low. |
| Keywords: | anticancer cyanobacteria microalgae natural products pharmaceutical |