On-line measurement of cell mass and specific growth rate by a laser turbidity meter coupled with data smoothing using a one-pass method |
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| Authors: | J Horiuchi M Kishimoto H Momose |
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| Institution: | (1) Bioprocess and Chemical Process Development Department, Research Center, Toyo Engineering Corporation, 1818 Togoh, Mobara-shi, 297 Chiba, Japan;(2) Department of Biological Science and Technology, Science University of Tokyo, 2641 Yamazaki, Noda-shi, 278 Chiba, Japan |
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| Abstract: | Summary A data smoothing algorithm by a one-pass method, employing spline function was applied to a laser turbidity meter for on-line measurement of cell mass and specific growth rate in the culture using recombinant E.coli The outputs from the laser turbidity meter containing noise and errors were successfully filtered by the method, leading to more reliable estimation of cell mass and specific growth rate in real time. |
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