The mechanism of calcium-dependent activation of respiration of liver mitochondria from hibernating ground squirrels,Citellus undulatus |
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| Institution: | 1. Measurement Science and Standards, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada;2. Department of Molecular Genetics, University of Toronto, 1 King''s College Circle, Toronto, Ontario M5S 1A8, Canada;3. Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada |
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| Abstract: | - 1.1. It is shown that Ca2+-dependent activation of respiration of liver mitochondria from hibernating ground squirrels is accompanied by mitochondrial swelling.
- 2.2. The swelling of mitochondria from hibernating ground squirrels, as well as the activation of mitochondrial respiration, is precluded by cyclosporin A, p-bromphenacylbromide and oligomycin. Carboxyatractiloside, on the contrary, under these conditions favors the swelling and the acceleration of respiration.
- 3.3. It was concluded that Ca2+-dependent activation of hibernating ground squirrel liver mitochondrial respiration resulted from the appearance of a non-specific permeability pathway and from swelling of mitochondria.
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