Drosophila protein tyrosine phosphatases |
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| Institution: | 1. Departments of Biochemistry, University of Iowa, College of Medicine, Iowa City, IA 52242, USA;2. Anatomy and Cell Biology, University of Iowa, College of Medicine, Iowa City, IA 52242, USA;1. PKU-THU Joint Center for Life Sciences, College of Life Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China;2. Gene Regulatory Lab, School of Medicine, Tsinghua University, Beijing, 100084, China;4. Tsingdao Advanced Research Institute, Tongji University, Qingdao, 266000, China;1. Department of Pediatrics, School of Medicine, Ewha Womans University, 911–1 Mok-Dong, Yang Cheon-Gu, Seoul 158-710, Republic of Korea;2. Department of Biochemistry, School of Medicine, Ewha Womans University, 911–1 Mok-Dong, Yang Cheon-Gu, Seoul 158-710, Republic of Korea;3. Department of Microbiology, School of Medicine, Ewha Womans University, 911–1 Mok-Dong, Yang Cheon-Gu, Seoul 158-710, Republic of Korea;4. Department of Pathology, School of Medicine, Ewha Womans University, 911–1 Mok-Dong, Yang Cheon-Gu, Seoul 158-710, Republic of Korea;5. Department of Otorhinolaryngology–Head and Neck Surgery, School of Medicine, Ewha Womans University, 911–1 Mok-Dong, Yang Cheon-Gu, Seoul 158-710, Republic of Korea;6. Department of Molecular Medicine, School of Medicine, Ewha Womans University, 911–1 Mok-Dong, Yang Cheon-Gu, Seoul 158-710, Republic of Korea;7. Department of Ewha Global Top 5 Research Program, School of Medicine, Ewha Womans University, 911–1 Mok-Dong, Yang Cheon-Gu, Seoul158–710, Republic of Korea;1. Institute of Biophysics SB RAS, Federal Research Center “Krasnoyarsk Science Center SB RAS”, Krasnoyarsk, 660036, Russia;2. Siberian Federal University, Krasnoyarsk, 660041, Russia |
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| Abstract: | Seven protein tyrosine phosphatase (PTPase) genes have been identified in the fruit-fly Drosophila melanogaster. Four of these genes encode receptor-linked PTPases (R-PTPs) that are expressed on central nervous system axons in the embryo. Each axonal R-PTP has an extracellular domain that is homologous to vertebrate adhesion molecules and to identified mammalian R-PTPs. Two non-receptor PTPase genes have been isolated to date. One of these, corkscrew (csw), encodes an SH2 domain-containing PTPase that appears to be a homolog of mammalian PTP1D. Genetic evidence indicates that the csw PTPase is involved in the transduction of signals from receptor tyrosine kinases to their down-stream targets, which include Ras proteins. |
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