Simultaneous analyses of monoamines and their metabolites in urine specimens of patients with neuroblastoma |
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| Affiliation: | 1. Science for Life Laboratory, KTH–Royal Institute of Technology, 17165 Stockholm, Sweden;2. Department of Biology and Biological Engineering, Chalmers University of Technology, 41260 Gothenburg, Sweden;3. Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland;4. MRC Epidemiology Unit, University of Cambridge, CB2 0QQ Cambridge, UK;5. Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg 41345, Sweden;6. University of Leipzig, Department of Medicine, 04103 Leipzig, Germany;7. CNR Institute of Clinical Physiology, 56126 Pisa, Italy;8. Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum, 00290 Helsinki, Finland;9. Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland;10. Baker IDI Heart and Diabetes Institute, Melbourne, VIC 3004, Australia;1. Department of Gynaecology and Obstetrics, Tongren Hospital, Shanghai Jiaotong University School of Medicine, 1111XianXia Road, Shanghai 200336, China;2. School of Medicine, Suzhou University, Suzhou 215021, China;3. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing 100700, China;1. Department of Animal and Human Physiology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland;2. Department of Pharmaceutical Chemistry, Medical University of Gdańsk, Hallera 107, 80-416, Gdańsk, Poland;1. Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, Huzhou 313001, China;2. School of Physics, University of Electronic Science and Technology of China, Chengdu 610054, China;3. Department of Physics, Chongqing Key Laboratory for Strongly Coupled Physics, Chongqing University, Chongqing 401331, China |
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| Abstract: | 1. Tyrosine and tryptophan, as well as 26 metabolites of these amino acids, were analyzed simultaneously in urine specimens from patients with neuroblastoma and control infants by a three-dimensional HPLC system to develop an early diagnosis.2. Levels of detected compounds in urine from patients with neuroblastoma were generally higher in the case of catecholamines and lower in the case of indolalkylamines than those in controls.3. The pathways of Dopamine-3,4-Dihydroxyphenylacetic acid-Vanillylmandelic acid, Dopamine-3-Methoxy-4-hydroxyphenylethylene glycol-Vanillylmandelic acid-Vanillic acid and Tyrosine-4-Hydroxy-phenylacetic acid-4 were, in particular, found to be active in patients with neuroblastoma. |
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