Measurement of blood flow in the skin and oral mucosa of the rhesus monkey (Macaca mulatta) using laser doppler flowmetry |
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| Institution: | 1. Department of Otolaryngology, University of Iowa, Iowa City, IA 52242, U.S.A.;2. Dows Institute for Dental Research, University of Iowa, Iowa City, IA 52242, U.S.A. (Tel. 319-335-7407; Fax 319-335-8895);4. Dows Institute for Dental Research, University of Iowa, Iowa City, IA52242, U.S.A.;1. Bioimaging, GlaxoSmithKline, King of Prussia, PA 19406, USA;2. College of Nanoscale Science, SUNY Polytechnic Institute, Albany, NY 12203 USA;3. Wadsworth Center, New York State Department of Health, Albany, NY 12201 USA;1. Minase Research Institute, Ono Pharmaceutical Co., Ltd., 3-1-1, Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan;2. Preclinical Research Unit, Sumitomo Dainippon Pharma Co., Ltd., 3-1-98 Kasugadenaka, Konohana-ku, Osaka 554-0022, Japan;3. Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan;4. Laboratory for Chemistry, Manufacturing and Control Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation, 632-1 Mifuku, Izunokuni, Shizuoka 410-2321, Japan;5. Drug Metabolism & Pharmacokinetics, Research Laboratory for Development, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka-shi, Osaka 561-0825, Japan;6. Medical Analysis Research Department, Towa Pharmaceutical Co., Ltd., 134 Chudoji Minami-machi, Shimogyo-ku, Kyoto 600-8813, Japan;7. Clinical PK/PD Department, Nippon Boehringer Ingelheim Co., Ltd., 6-7-5 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan;8. Pharmacokinetics and Non-Clinical Safety Department, Nippon Boehringer Ingelheim Co., Ltd., 6-7-5 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan;9. Biological Research Department, Sawai Pharmaceutical Co., Ltd., 5-2-30, Miyahara, Yodogawa-ku, Osaka 532-0003, Japan;10. Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga 525-8577, Japan;11. Molecular Pharmaceutics Laboratory, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga 525-8577, Japan;1. Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Cambridge, Massachusetts 02139;2. Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06345 |
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| Abstract: | - 1.1. It is generally assumed that oral blood flow is higher than that of skin, and invasive methods to measure blood flow support this view.
- 2.2. However, it was not known whether this finding would be confirmed by laser Doppler flowmetry, which is a noninvasive method to measure blood flow.
- 3.3. The purpose of this study was to compare blood flow in oral and skin regions of the rhesus monkey using laser Doppler flowmetry.
- 4.4. The results demonstrated that blood flow was significantly higher in oral regions as compared to facial skin (P < 0.05).
- 5.5. This finding is most likely related to the more abundant capillary supply in oral mucosa as compared to skin.
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