2-Deoxyglucose transport by the frog sartorius: Effects of electrical stimulation and N-carbobenzoxy-glycyl-l-phenylalaninamide |
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| Affiliation: | 1. Department of Physiology and Neurobiology, University of Connecticut, 75 N. Eagleville Rd, Storrs, CT 06269, USA;2. Department of Internal Medicine, Section of Digestive Diseases, Yale University, 333 Cedar St, New Haven, CT 06510, USA;1. The Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA;2. Department of Neuroscience and Peter O''Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA;3. Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA;4. Huntsman Mental Health Institute, Department of Psychiatry, University of Utah, Salt Lake City, UT, USA;5. Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA;1. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA;2. The University of Sydney, Brain and Mind Centre & School of Medical Sciences, Sydney, NSW, Australia;3. University of Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, Lille, France;4. Mouse Behavior Core, Department of Genetics, Harvard Medical School, Boston, MA, USA |
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| Abstract: | - 1.1. Studies characterizing glucose transport in the frog sartorius were performed.
- 2.2. For nonstimulated and stimulated muscles, intracellular 2-deoxyglucose exceeded 2-deoxyglucose-6-phosphate at 15 min, showed little further increase, and was maintained below the extracellular concentration for 2 hr.
- 3.3. Accumulated 2-deoxyglucose-6-phosphate did not inhibit glucose transport.
- 4.4. Unlike in adipocytes, basal and stimulated 2-deoxyglucose transport showed no difference in sensitivity to N-carbobenzoxy-glycyl-l-phenylalaninamide.
- 5.5. Phenylarsine oxide blocked contraction-enhanced 2-deoxyglucose uptake.
- 6.6. These results suggest that the glucose transporter of the sartorius exhibits auto-regulation, and that basal transport is not regulated by the same process as in adipocytes.
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