Nicotine stimulates maturational gonadotropin (GtH2) release from carp (Cyprinus carpio L.) pituitary cells |
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| Affiliation: | 1. Laboratoire de Physiologie des Poissons I.N.R.A., Campus de Beaulieu, 35042 Rennes, France;1. Department of Ichthyobiology and Fisheries, Agricultural Academy, 30149 Krakow-Mydlniki, Poland;1. Petrobras, Rua República do Chile 330, Rio de Janeiro, RJ, 20031-170, Brazil;2. Department of Mechanical Engineering, Pontifícia Universidade Católica do Rio de Janeiro, Rua Marquês de São Vicente 225, Rio de Janeiro, RJ, 22453-900, Brazil;3. Department of Mathematics and Department of Mechanical Engineering, University of British Columbia, 1984, Mathematics Road, Vancouver, BC, Canada, V6T 1Z2;1. Clinical Assistant Professor, Department of General Dental Sciences, Marquette University School of Dentistry, Milwaukee, Wis;2. Assistant Professor and Director, Predoctoral Prosthodontics and Biomaterials, Department of General Dental Sciences, Marquette University School of Dentistry, Milwaukee, Wis;1. Department of Food Animal Clinics, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, 50100, Thailand;2. Integrative Research Center for Veterinary Preventive Medicine, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, 50100, Thailand;3. Faculty of Animal Science and Technology, Maejo University, Chiang Mai, 50290, Thailand;4. Department of Veterinary Biosciences and Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, 50100, Thailand;5. Excellent Center in Veterinary Biosciences (ECVB), Chiang Mai University, Chiang Mai, 50100, Thailand |
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| Abstract: | 1. Perifusion of dispersed pituitary cells and pituitary cell culture was used to investigate the effects of cholinergic drugs on the secretion of maturational gonadotropin (GtH2) in carp.2. Nicotine strongly, and in a dose dependent manner, stimulated GtH2 release in male and in female carp (from 10−8M in the Perifusion and 10−10M in the cells cultures).3. Nicotine is 10 times more active in females than in males.4. The results suggest that in carp, nicotine stimulates GtH2 release directly from the pituitary cells, indicating a possible involvement of a cholinergic system in the regulation of GtH2 secretion in teleost fish. |
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