Cholecystokinin modulates isoproterenol induced changes in rat parotid gland |
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| Affiliation: | 1. Departments of Oral Biology, University of Florida Health Science Center, Gainesville, FL 32610, U.S.A;3. Pharmacology and Therapeutics, University of Florida Health Science Center, Gainesville, FL 32610, U.S.A;2. Department of Oral Biology, Semmelweis University, Budapest, Hungary;1. School of Natural Resources and Environment, University of Florida, Gainesville, FL, 32603, USA;2. Whitney Laboratory for Marine Bioscience, University of Florida, St. Augustine, FL, 32080, USA;3. St. Mary''s College of Maryland, St. Mary''s City, MD, 20686, USA;4. Levin College of Law, University of Florida, Gainesville, FL, 32603, USA;5. Environmental Engineering Sciences, Center for Coastal Solutions, University of Florida, Gainesville, FL, 32603, USA;1. College of Food Science and Technology, Northwest University, Xi''an, 710069, China;2. College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China;1. Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, NJ, 08854, United States;2. Anton Paar Quantatec Inc., 1900 Corporate Dr, Boynton Beach, FL, 33426, United States;3. Department of Chemical and Bioengineering, Institute of Separation Science and Technology, Friedrich-Alexander University Erlangen-Nürnberg, 91058, Erlangen, Germany;1. State Key Laboratory of Ultra-precision Machining Technology, Department of Industrial and Systems Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China;2. Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, 518060, China;3. Guangdong Province Key Laboratory of Durability for Marine Civil Engineering, School of Civil Engineering, Shenzhen University, Shenzhen, Guangdong, 518060, China;1. Department of Mechanical Engineering, Kuwait University, PO Box 5969 Safat 13060, Kuwait;2. Department of Mechanical Engineering, Dezful Branch, Islamic Azad University, Dezful, Iran;3. Department of Mechanical Engineering, Faculty of Engineering, Lorestan University, Iran;1. Department of Biology, Faculty of Science, University of Shahrekord, P. O. Box. 115, Shahrekord, Iran;2. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran |
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| Abstract: | 1. Parotid gland secretory function and activity of several enzymes involved in intracellular second messenger signalling were measured in rats receiving 0.5 ml i.p. injections of saline (control), isoproterenol, CCK or both drugs.2. Isoproterenol caused a 2.5-fold increase in parotid gland wet weight compared to control. Chronic administration of CCK alone has no effect on gland weight. A combination of CCK and isoproterenol did not alter the hypertrophy of the gland observed with isoproterenol alone.3. Isoproterenol administration caused a 74% decrease in parotid gland amylase enzyme activity. While CCK alone did not influence the enzyme activity, it depressed amylase mRNA steady state levels and had an additive effect on further decreasing mRNA levels when administered in combination with β-agonist.4. Phospholipase C registered an increase ranging from 22 to 38% in all experimental groups as compared to control.5. Parotid gland protein kinase C and PdtIns 3-kinase activity were not altered in response to CCK alone, but in combination with isoproterenol, appeared to moderate β-agonist signal transduction responses. |
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