Cytotoxic T lymphocytes in HIV infection |
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| Institution: | 1. Department of Maxillofacial and Plastic Surgery, Rare Diseases Reference Center Coordinator for Clefts and Facial Malformations, Hôpital Universitaire Necker-Enfants Malades, Paris, France;2. Université Paris Descartes-Sorbonne Paris Cité, Paris, France;3. Department of Pathology, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, and Université Paris Descartes, Paris, France;4. Cantonal Institute of Pathology, Locarno, Switzerland;5. Department of Health Sciences, University of Eastern Piedmont, Novara, Italy;6. Genomic of Solid Tumors Department, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris; Université Paris-Diderot, Sorbonne Paris Cité, Paris, France |
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| Abstract: | Infection with human immunodeficiency virus (HIV) induces potent cytotoxic T lymphocyte (CTL) response. Their level of activity is often extraordinary high, which in the presence of normal precursor levels suggests that effector CTL may be overstimulated and terminally differentiated. Late in HIV infection the CTL response declines. Possible mechanisms for this are discussed, including clonal exhaustion, lack of T cell help and virus escape by mutations involving epitope sequences. Evidence for the last is presented. Such escape potential implies that CTL are important in controlling the virus infection and that HLA type could have an effect on outcome. Escape mutation also has implications for vaccine design. |
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