Transmembrane control of cadherin-mediated cell-cell adhesion |
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| Affiliation: | 1. ICAR-National Institute of Animal Nutrition and Physiology (ICAR-NIANP), Bangalore 560030, India;2. Department of Veterinary Biochemistry, Veterinary College, Bangalore 560024, India;1. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands;2. Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands;3. Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany;4. Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania;1. Department of Molecular & Integrative Physiology, University of Michigan Medical School, 7744 Medical Science Building II, 1301 E. Catherine, Ann Arbor, MI 48109, United States;2. Department of Medicine, University of Michigan Medical School, 7744 Medical Science Building II, 1301 E. Catherine, Ann Arbor, MI 48109, United States;3. Ann Arbor Health System VA Medical Center, United States;1. Research & Development, Protein and Cell Analysis, Thermo Fisher Scientific, Bangalore, India;2. Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA;3. Department of Pathology, University of Michigan, Ann Arbor, MI, USA;4. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA;5. Applied Biomics, Freemont, CA, USA;6. Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China;7. VA Ann Arbor Healthcare System, Ann Arbor, MI, USA;1. Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York;2. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York;3. Center for Clinical Trials, Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland;4. Department of Ophthalmology, University of Wisconsin, Madison, Madison, Wisconsin |
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| Abstract: | The cadherin family of cell-cell adhesion molecules plays a central role in organization of cells into multicellular structures. An important feature of the action of cadherins is that they form a complex with cytoskeletal proteins, and the formation of this complex is crucial for their adhesive function. Cadherin-mediated cell adhesion is thus controlled through the interaction with cytoplasmic proteins, and, for such control, phosphorylation of these proteins and also cadherins themselves might be involved. This regulatory mechanism of cell adhesion is perhaps fundamental to a variety of morphogenetic processes. |
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