Peritubular Na-K exchange ion pump in maleate-treated frog kidney proximal tubular cells |
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| Affiliation: | 1. Department of Radiology, Royal Hospital for Sick Children, 9 Sciennes Rd, Edinburgh EH9 1LF, UK;2. The Children’s Hospital, Oxford University Hospitals, Oxford, UK;1. SAP Alt Penedès-Garraf-Baix Llobregat Nord. Institut Català de la Salut, Vilanova i la Geltrú, España;2. ABS Penedès rural. Institut Català de la Salut, Vilafranca del Penedès, España;3. Medicina Interna, Hospital Comarcal de l’Alt Penedès, Vilafranca del Penedès, España;4. ABS Sant Sadurní d’Anoia, Institut Català de la Salut, Sant Sadurní d’Anoia, España;1. Department of Gastroenterology, Post Graduate Institute of Medical Education & Research, Chandigarh, India |
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| Abstract: | - 1.1. After perfusion of isolated frog kidneys for 1 hr with 10−3 or 10−2 M maleate Ringer, the peritubular membrane potential gradually declined in a dose-dependent manner.
- 2.2. The ouabain-like effects of maleate on cell Na and K activities were dose-dependent and smaller than the effects of zero K or 10−4M ouabain. Intracellular pH was not altered in the presence of 10−2M maleate.
- 3.3. The driving force for Na entry into the cell was reduced, respectively, to 81.4 and 58.4% (of control) in the presence of 10−3 and 10−2 M maleate.
- 4.4. There was no histochemically detectable inhibition of proximal tubule Na-K ATPase activity during 3 hr of perfusion with 10−2 M maleate.
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