Refeeding after 72 hour fasting alters neuropeptide Y and monoamines in various cerebral areas in the rat |
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| Affiliation: | 1. Laboratoires de Toxicologie, Faculté de Pharmacie, Châtenay-Malabry, France;3. Laboratoires de, Pharmacologie, Faculté de Pharmacie, Châtenay-Malabry, France;1. UCL Division of Medicine, University College London, London, UK;2. UCL Centre for Rheumatology and Connective Tissue Diseases, Royal Free Hospital, London, UK;3. University of Michigan, Ann Arbor, MI, USA;1. Department of Medicine, Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA;2. Harvard Medical School, Boston, MA, USA;3. Department of Medicine, Division of Endocrinology, Neuroendocrinology Unit, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;4. Center for Human Integrative Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;5. Department of Medicine, Division of Genetics, Brigham and Women''s Hospital, Boston, MA, USA;6. Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;7. Quantitative Biomedical Research Center, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA;1. Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, CV2 2DX, United Kingdom;2. Aston Medical School, College of Health and Life Sciences, Aston University, Birmingham, B4 7ET, United Kingdom;3. School of Biosciences, College of Health and Life Sciences, Aston University, Birmingham, B4 7ET, United Kingdom;4. Warwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom;5. Centre of Applied Biological & Exercise Sciences, Faculty of Health & Life Sciences, Coventry University, Coventry, CV1 5FB, United Kingdom;6. Centre for Sport, Exercise and Life Sciences, Research Institute for Health & Wellbeing, Coventry University, CV1 5FB, United Kingdom;1. Department of Industrial Engineering, Faculty of Engineering, Shahed University, Tehran, Iran;2. Université de Nantes & LS2N UMR CNRS 6004, Nantes, France |
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| Abstract: | - 1.1. Monoamine turnover and neuropeptide Y (NPY) levels were evaluated in the CNS of adult male rats either after fasting (72 hr) or refeeding.
- 2.2. In the fasted group, an overall increase in NPY levels was observed except in the striatum where it was decreased. The serotoninergic turnover was decreased in the hippocampus, striatum and cortex.
- 3.3. After refeeding, NPY decreased in the hypothalamus and cortex but was further increased in the hippocampus and decreased in the striatum. The serotoninergic turnover was still decreased in the hippocampus and cortex. The norepinephrine levels and the dopaminergic turnover increased in the hippocampus and cortex.
- 4.4. No relationship appeared between NPY and monoamine changes suggesting that NPY can act independently in feeding behavior, and play, in different brain areas, an important role in its regulation.
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